Kliniska studier vid Tema Cancer
–Studier öppna för inklusion inom PO Hematologi–
Här visas de studier som är öppna för patientinklusion inom den medicinska enheten (ME). Studierna är uppdelade på de olika patientflödena. Vidare visas ansvarig prövare, forskningssjuksköterska och planerad och aktuell inklusion inom temat (visas ej utanför Karolinska). Listan uppdateras minst en gång i veckan. -Längst ner finns en förklaring till de olika kolumnerna.
Benmärgssvikt och leukemi
| Nr | Namn | Fas |
Startdatum | Ansvarig prövare |
19/010 |
Labmarkörer MPN-patienter . Labmarkörer som en del av riskbedömning för trombohemorrhagiska komplikationer hos patienter med myeloproliferativa sjukdomar |
Ej tillämpbar |
2021-12-06 |
Roza Chaireti |
19/051 |
MAATEO. A phase 1 study in MDS, AML and ALL patients to evaluate safety, tolerability and efficacy of Karonudib |
1 |
2019-10-03 |
Stefan Deneberg |
20/016 |
HOVON 150. A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acutemyeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy |
3 |
2021-01-27 |
Martin Jädersten |
20/018 |
EVI-3: Combining Active and Passive DNA Hypomethylation. EVI-3: Combining Active and Passive DNA Hypomethylation A multicenter, randomized, parallel-group, placebo-controlled phase II study of the efficacy and safety of oral vitamin C supplement in combination with azacitidine in higher-risk MDS, CMML, and low-blast-count AML |
3 |
2021-04-15 |
Eva Hellström Lindberg |
22/017 |
LD-VenEx. LD-VenEx Clinical Study Protocol: Phase 2 study of azacitidine in combination with low dose intensity venetoclax in patients with acute myeloid leukemia with integration of explorative multi-omics and ex vivo drug screening data |
2 |
2023-05-10 |
Martin Jädersten |
24/004 |
MK3543-007 (Shorespan-007). A phase 3, Randomized, Double-blind, Active.Comparator-Controlled Clinical Study to Evaluate the Efficacy and Safety of Bomedemstat (MK3543) versus Hydroxyurea in Cytoreductive Therapy Naive Essential thrombocythemia Partiocipants |
3 |
2024-11-29 |
Anna Ravn Landtblom |
24/067 |
RENEW-KER-050-D301. A Phase 3, Randomized, Double-blind, Placebo-Controlled Study toEvaluate the Efficacy and Safety of Elritercept in Adult Participantswith Very Low, Low, or Intermediate Risk MyelodysplasticSyndromes (MDS) with Anemia |
3 |
2025-04-29 |
Magnus Tobiasson |
25/012 |
Lumina 3. A phase 3, multicenter, randomized, double-blind, placebo controlled, parallel-group study with an open-label period and long-term extension to assess the efficacy and safety of rilzabrutinib in participants with warm autoimmune hemolytic anemia (wAIHA) |
3 |
2025-08-15 |
Cecilia Karlström |
Lymfom
| Nr | Namn | Fas |
Startdatum | Ansvarig prövare |
17/413 |
Immunologiska lab-studier på patienter med KLL och andra hematol. In vitro studier av immunologiska funktioner hos patienter med kroniska lymfoproliferativa tumörsjukdomar (Myelom, lymfom, KLL) och MGOS: Extra blodprovstagning |
Ej tillämpbar |
2018-01-01 |
Anders Österborg |
18/032 |
BioLymph. Prospektiv studie av biologi, etiologi och överlevnad vid lymfom (BioLymph). |
Ej tillämpbar |
2019-02-14 |
Karin Ekström Smedby |
18/073 |
PRO-Hodgkin. Clinical investigation of PBS proton treatment in Hodgkin lymphoma patients |
2 |
2019-11-06 |
Lotta Hansson |
20/007 |
DSA-LL-studien. Better and individualised therapy for patients with relapsing lymphoma and leukaemia |
Ej tillämpbar |
2021-09-01 |
Björn Wahlin |
20/058 |
ALLTogether-1. ALLTogether1– A Treatment study protocol of the ALLTogether Consortium for children and young adults (1-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL) |
3 |
2020-09-01 |
Joel Joelsson |
21/104 |
BGB3111-LTE1 Roll-overstudie. En öppen, multicenter, långsiktig förlängningsstudie av zanubrutinib (BGB-3111) hos patienter med Bcellsmaligniteter. |
4 |
2022-05-10 |
Björn Wahlin |
22/073 |
BELLWAVE-011 (MK1026-011). A Phase 3, Randomized Study to Compare the Efficacy and Safety ofNemtabrutinib Versus Ibrutinib as 1L+ Therapy in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BELLWAVE-011) |
3 |
2024-10-10 |
Anders Österborg |
24/060 |
HYPERION. Hyper-CVAD/MA for high-risk aggressive B-cell lymphomas: a single-centre academic phase II trial |
2 |
2024-11-08 |
Björn Wahlin |
24/068 |
SOUNDTRACK-B. A Modular Phase II, Single-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of AZD0486 in Participants with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma |
2 |
2025-05-06 |
Björn Wahlin |
25/019 |
NLG-FL7 FLIRT. Primary treatment of follicular lymphoma with rituximab-lenalidomide-tafasitamab for high-risk disease and rituximab-lenalidomide with a 1:1 randomization to tafasitamab for low-risk disease: a phase II study – NLG-FL |
2 |
2025-06-05 |
Björn Wahlin |
25/044 |
BGB-11417-303. A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma |
3 |
2025-12-01 |
Lotta Hansson |
25/047 |
BGB-16673-304. A Phase 3, Open-Label, Randomized Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphom |
3 |
2026-02-23 |
Anders Österborg |
Myelom
| Nr | Namn | Fas |
Startdatum | Ansvarig prövare |
22/009 |
MAGNETISMM-7-studie. A randomised, 2-arm, phase 3 study of elranatamab (PF-06863135) versus lenalidomide in patients with newly diagnosed multiple myeloma who are minimal residual disease-positive after undergoing autologous stem-cell transplantation |
3 |
2022-09-08 |
Katarina Uttervall |
22/043 |
MajesTEC-7. A Phase 3 Randomized Study Comparing Teclistamab in Combination with Daratumumab SC and Lenalidomide (Tec-DR) versus Daratumumab SC, Lenalidomide, and Dexamethasone (DRd) in Participants with Newly Diagnosed Multiple Myeloma Who are Either Ineligible or not Intended for Autologous Stem Cell Transplant as Initial Therapy |
3 |
2022-12-22 |
Katarina Uttervall |
22/044 |
ODX-MM-001. A Phase I/IIa Study of ODX (OsteoDex) in Multiple Myeloma |
1-2 |
2023-03-28 |
Katarina Uttervall |
Koagulation
| Nr | Namn | Fas |
Startdatum | Ansvarig prövare |
19/011 |
A-EKG-HemA. Kardiovaskulära risker och mikropartiklarnas roll i en åldrade population av patienter med hemofili A under olika behandlingsregim |
Ej tillämpbar |
2019-12-05 |
Roza Chaireti |
26/018 |
LIBERTY- Sobi.BIVV001-002 . A multinational, prospective, open-label, roll-over study (LIBERTY) to provide post-trial access to treatment for patients with severe haemophilia A who have completed a previous trial with efanesoctocog alfa |
4 |
2026-03-06 |
Maria Magnusson |
Nr: Forskningsrådets nummer.
Namn: Studiens kortnamn följt av protokollets hela titel.
Fas: Kan vara Fas 1, 2, 3 eller Pilot, kombinationer av dessa, eller Ej tillämpligt.
Startdatum: Vanligen datum för startmöte eller
liknande.
Ansvarig prövare: Den läkare som är ansvarig
för studien inom Tema Cancer.
Ansvarig forskn.sköt: Den forskningssjuksköterska
som är ansvarig.
CKC, Tema Cancer, Karolinska universitetssjukhuset 29.05.2026