Kliniska studier vid Tema Cancer

–Studier öppna för inklusion inom PO Bäckencancer–

Här visas de studier som är öppna för patientinklusion inom den medicinska enheten (ME). Studierna är uppdelade på de olika patientflödena. Vidare visas ansvarig prövare, forskningssjuksköterska och planerad och aktuell inklusion inom temat (visas ej utanför Karolinska). Listan uppdateras minst en gång i veckan. -Längst ner finns en förklaring till de olika kolumnerna.

Kolorektal cancer

 Nr Namn

Fas

Startdatum Ansvarig prövare

20/053

PRORECT. Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT): A Prospective Randomized Swedish Phase II Trial

2

2021-03-08

Alexander Valdman

20/073

CIM-HIPEC. The native immune system and the development of carcinomatosis among patients with colorectal cance

Ej tillämpbar

2020-01-10

Caroline Nordenvall

20/074

CIM-IBD. Single-cell analysis of intestinal lymphocytes reveals targets for treatment of inflammatory bowel disease

Ej tillämpbar

2019-06-13

Caroline Nordenvall

20/075

CITCCA pilot. CIrculating Tumour DNA in Colorectal CAncer, pilotstudie

Ej tillämpbar

2020-10-22

Anna Martling

20/076

CRUISE. Restorative treatment with ileorectal anastomosis or ileal pouch anal anastomosis in patients with ulcerative colitis

Ej tillämpbar

2017-03-01

Caroline Nordenvall

21/046

EFFIPEC. EFFIPEC – Efficacy of Hyperthermic Intraperitoneal Chemotherapy Single-arm Phase I study, followed by an open-label, randomized, controlled registry-based phase III trial

1

2022-10-30

Gabriella Palmer

22/019

PelvEx II. Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer

3

2022-08-17

Henrik Iversen

24/063

SCAR-studien. Operation eller behandling med koloskop efter borttagande av tidig tarmcancer (SCAR-studien)

Ej tillämpbar

2025-11-01

Richard Marsk

24/083

TRIOCOL. TRIOCOL - the study of third-line advanced drug treatment vs colectomy in patients with ulcerative coliti

Ej tillämpbar

2024-11-03

Caroline Nordenvall

24/088

SELSA. Selective defunstionen stoma approach in low anterior resection for rectal cancer(SELSA): a prospective study and a nested randomised clinical trial

Ej tillämpbar

2024-10-31

Naseer Baloch

25/084

Komplikationer efter rektalcancer/carcinoskirirgi. Förekomst av komplikationer efter rektalcancer- och carcinoskirurgi samt påverkan på tarmnfunktion och livskvalitet

2025-02-12

Mirna Abraham Nordling

Gynekologisk cancer

 Nr Namn

Fas

Startdatum Ansvarig prövare

18/080

RACC. The RACC trial -Robot Assisted Approach to Cervical Cancer

3

2019-05-27

Henrik Falconer

19/044

SCAN-Mi-studien-cervix. Mikrobiomets associerade biomarkörers betydelse för utveckling och prognos av livmoderhals- och huvudhals-cancer.

Ej tillämpbar

2021-05-01

Henrik Falconer

19/058

TITANIUM. GestaTIonal TrophoblAstic NeoplasIa assessMent

Ej tillämpbar

2022-01-01

Ulrika Joneborg

21/107

GeMore-studien. Genetisk och molekylär kartläggning samt riktad behandling inom gynekologisk cancer

Ej tillämpbar

2021-01-02

Josefin Fernebro

21/108

ISGA-studien (pre-GAT01). studier av immunsystemet hos patienter med gyncancer

Ej tillämpbar

2021-10-21

Emelie Wallin

22/077

ct-DNA-studien på cervixcancer. Analys av cell-fritt tumör-DNA i blod.

Ej tillämpbar

2022-01-01

Kristina Hellman

23/004

PARP-PET. [11C]AZ14193391 - PET as a selection tool for treatment with PARP inhibitors in patients with metastatic solid tumors

Ej tillämpbar

2025-01-30

Josefin Fernebro

23/028

FOLERO. Frailty, quality Of Life and Early Reversal of temporary defunctioning Stoma in Ovarian Cancer

Ej tillämpbar

2024-02-29

Sahar Salehi

24/079

GROINSS VIII. GROningen INternational Study on Sentinel node in Vulvar Cancer III, a prospective phase II treatment trial

2

2025-05-02

Christina Hellman

24/093

DESTINY-Ovarian01 (DS8201-772). A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer

2026-01-16

Hanna Dahlstrand

25/010

DESTINY-Endometrial01 (DS8201-772)- D781DC00001. DESTINY-Endometrial01: An Open-Label, Sponsor-Blinded, Randomized, Controlled, Multicenter, Phase III Study of Trastuzumab Deruxtecan (T-DXd) Plus Rilvegostomig or Pembrolizumab vs Chemotherapy Plus Pembrolizumab as First-Line Therapy of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR), Primary Advanced or Recurrent Endometrial Cancer

3

2026-01-29

Emelie Wallin

25/027

BNT323-01 /ENGOT-EN2. A Phase III, randomized, multi-site, open-label trial of BNT323/DB-1303 versus investigator’s choice of chemotherapy in previously treated patients with HER2-expressing recurrent endometrial cancer

3

2026-03-09

Hanna Dahlstrand

25/086

DARSH-studien. Day care in Robotic Surgery Hysterectomy. Jämförande studie mellan dagvård och inneliggande vård vid robot-assisterad hysterektomi

2025-08-01

Vilhelm Mörlin

Prostatacancer

 Nr Namn

Fas

Startdatum Ansvarig prövare

14/37

SPCG-15. Primary radical prostatectomy versus primary radiotherapy for locally advanced prostate cancer: an open randomized clinical trial

3

2014-10-01

Mats Olsson

18/034

PSMA recidiv-studien. En randomiserad jämförelse mellan konventionell "Salvage" strålbehandling och individualiserad PSMA-pet styrd behandling hos patienter med biokemiskt återfall (PSA) efter prostatacancer operation

2

2018-10-30

Stefan Karlsson

18/066

ProBio . ProBio: An outcome-adaptive and randomized multi-arm biomarker driven study in patients with metastatic castrate resistant prostate cancer mCRPC)

2

2019-05-27

Anders Ullén

21/023

MK3475-365. Phase Ib/II Trial of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

1-2

2022-04-01

Enrique Castellanos

21/048

PRIS. Prostate Cancer IRE Study (PRIS) – A randomized controlled trial comparing focal to radical treatment in localized prostate cancer

3

2022-09-07

Anna Lantz

22/038

METRO. Metastasis directed Stereotactic Body Radiotherapy (SBRT) for Oligo metastatic Hormone sensitive Prostate Cancer

3

2023-10-19

Mattias Hedman

23/068

CAAA617A12402. Phase IV, Post-Authorization Safety Study to Investigate the Long-Term Safety of lutetium (177Lu) vipivotide tetraxetan in Adult Participants with Prostate Cancer

4

2024-01-30

Enrique Castellanos

23/072

OMAHA-004. A Phase 3, Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) That Progressed On or After Prior Treatment with One Nextgeneration Hormonal Agent (NHA)

3

2024-06-01

Anna Kristiansen

24/016

IPA. Incontinence Post robot assisted radical prostatectomy, Anatomical and functional causes

Ej tillämpbar

2024-11-14

Stefan Carlsson

24/086

AMG509-Xalute. A Phase 3, Open-label, Multicenter, Randomized Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Subjects with Metastatic Castration-Resistant Prostate Cancer Previously Treated with Chemotherapy.

3

2025-05-25

Enrique Castellanos

24/092

RechARge-CA0711000. A Phase 3, Two-part, Randomized, Open-label, Adaptive Study Comparing BMS-986365 versus Investigator’s Choice of Therapy Comprising Either Docetaxel or Second Androgen Receptor Pathway Inhibitor (ARPI), in Participants with Metastatic Castration-resistant Prostate Cancer(mCRPC)

3

2025-05-30

Enrique Castellanos

25/014

MK2400-001-IDeate-Prostate01. A phase 3, open-label study of Ifinatamab Deruxtecan versus docetaxel in participants with metastatic castration-resistant prostate cancer (mCRPC)

3

2025-06-04

Anna Kristiansen

25/024

PARIS-BIO. Prostate Androgen Response Investigation using a Stratification BIOmarker

3

2025-11-03

Johan Björklund

25/062

EvoPAR02 Prostate02. A randomized, double-blind, placebo-controlled, phase 3 study of adjuvant Saruparib (AZD5305) in patients with localized high-risk prostate cancer receiving radiotherapy with androgen deprivation therapy (EvoPAR-Prostate02

3

2026-03-09

Anna Kristiansen

Blåscancer

 Nr Namn

Fas

Startdatum Ansvarig prövare

21/041

BioBladder. Biomarker profiling to predict response and survival in patients receiving systemic therapy for advanced urothelial cancer

Ej tillämpbar

2022-03-10

Anders Ullén

25/059

CA244-0012 / IZABRIGHT-BLADDER01. A Randomized, Open-Label, Phase 2/3 Trial Of Izalontamab Brengitecan Versus Platinum-Based Chemotherapy For Metastatic Urothelial Cancer In Participants With Disease Progression On Or After An Immunotherapy-Based Treatment

2-3

2026-03-11

Anders Ullén

Njur- och testikelcancer

 Nr Namn

Fas

Startdatum Ansvarig prövare

19/002

TINCA II - njurcancer. Det immunologiska landskapet i njurcancer

Ej tillämpbar

2021-09-01

Magnus Lindskog

Urologiska sjukdomar

Tyvärr är inga studier aktuella just nu.

Nr: Forskningsrådets nummer.
Namn: Studiens kortnamn följt av protokollets hela titel.
Fas: Kan vara Fas 1, 2, 3 eller Pilot, kombinationer av dessa, eller Ej tillämpligt.
Startdatum: Vanligen datum för startmöte eller liknande.
Ansvarig prövare: Den läkare som är ansvarig för studien inom Tema Cancer.
Ansvarig forskn.sköt: Den forskningssjuksköterska som är ansvarig.

CKC, Tema Cancer, Karolinska universitetssjukhuset 28.04.2026